GUILLAINE-BARRE SYNDROME (GBS) – CNS disorder characterized by bilateral,
symmetrical, polyneuritis leading to ascending muscle weakness/paralysis.
A.
Cause – IDIOPATHIC
B.
PREDISPOSING FACTORS
1.
Autoimmune
2.
antecedent viral
infection
3.
immunizations such
as your flu vaccine
C.
CLINICAL MANIFESTATION
1.
Clumsiness – initial sign
2.
Dysphagia
3.
Ascending muscle
weakness à paralysis
4.
Decreased DTRs
5.
Alternate
hypertension and hypotension; most
feared complication: arrhythmias
6.
Autonomic changes
§ Increased sweating and lacrimation
§ Increased salivation
§ Constipation
D.
DIAGNOSTICS
1.
CSF Analysis : reveals elevated CHON and IgG
§ CSF is
produced in the choroid plexus
E.
NURSING MANAGEMENT
1.
Maintain patent airway
and ventilation
§ Assist in mechanical ventilation
2.
Maintain side
rails (paralysis)
3.
prevent
complications of immobility
4.
institute NGT
feeding
5.
Administer
medications as ordered
§ Anticholinergics – Atropine Sulfate
§ Corticosteroids – to suppress immune response
§ Anti-arrhythmic agents
ü Lidocaine (Xylocaine)
ü Bretyllium – Blocks norepinephrine
ü Quinidines – anti-arrhythmic, anti-malarial (Malaria
–king of tropical diseases kaya ang meds ay queen = quinines) Common SE:
QUINCHONISM :
Q Female anopheles – malaria, night biting, lay eggs in
the morning
Q Female aegis egyptis – dengue, day biting, lay eggs at
night, 4 o’clock habit
Q Plasmodium falciparum – most dangerous form of malaria à hemorrhage
6.
Assist in
plasmaparesis
7.
Prevent
complications
§
Arrhythmias
§
Respiratory Arrest
